Global Commercial Oncology CDx Lead

ROLE SUMMARY At Pfizer Oncology, we are committed to “Outdo Cancer” by advancing transformative medicines wherever we can make a profound difference in the lives of patients. Today, Pfizer Oncology has an industry-leading pipeline that includes the combined legacy Pfizer and Seagen portfolio across breast, genitourinary, hematology-oncology, thoracic and gastrointestinal therapeutic areas.

The Global Commercial Oncology CDx Lead will drive commercial thought leadership on companion diagnostic global launch strategy for pre-launch oncology assets, including a potential first-in-class integrin-Beta-6 (IB6)-targeting antibody drug conjugate (ADC) sigvotatug vedotin (SV)

(should a companion diagnostic be needed) .

The first commercial launch could potentially be in 2L+ NSCLC in 2027.

The role requires demonstrated experience harmonizing commercial companion diagnostics global launch excellence and Rx launch strategy. Specific experience in global marketing, commercial strategy, market development and alliance management are core to the experience set.

ROLE RESPONSIBILITIES Lead the development and execution of global commercial companion diagnostic (CDx) launch strategies that are well-aligned with Rx launch strategies Develop and implement global market development plans to drive awareness of testing and adoption of new companion diagnostic solutions, including education, awareness, and stakeholder engagement. Lead and manage commercial diagnostic global partnerships to ensure aligned commercial strategies and joint value propositions for CDx and Rx; oversee joint steering committees Partner with Oncology R&D Clinical Diagnostics, Clinical Development, Global Medical Affairs, Regulatory, and Global Access & Value teams to ensure seamless incorporation of CDx commercial considerations into clinical development plans Partner with US and International commercial teams and Commercial Strategy & Innovation (CSI) to ensure alignment on target product profiles that may incorporate biomarker-selected populations, and global revenue assumptions on biomarker testing Deliver Global Guidance for Operating Plan and Long-Range Forecast assumptions for brands that require biomarker testing (i.e., global testing rates, HCP actionability rates) reflective of CDx aspiration as well as risk/benefit to medicine uptake by leveraging real world data Drive integration of CDx into specific tumor area treatment ecosystems to optimize patient identification and access to targeted therapies Work closely with Global Access & Value team and regional teams to support reimbursement strategies and health technology assessments for CDx. Identify and address barriers to CDx uptake, including logistical, operational, and economic challenges. Partner with Oncology Customer Analytics & Insights (CAI) to establish standardized KPIs and performance metrics to measure success of CDx initiatives globally. Develop detailed, strategic commercialization roadmaps and plans to ensure CDx launch readiness and appropriate planning assessments by partnering closely with the Chief Marketing Office Launch Excellence team. Build and maintain relationships with key external stakeholders, including diagnostic companies, healthcare providers, patient advocacy groups, and payers. Monitor global market trends, regulatory landscapes, and competitive intelligence to inform strategic decisions and anticipate future needs. Conduct all activities and make decisions that are in accordance with Company policies and SOPs, Pfizer Values & global regulatory guidelines, and requests consultation when navigating uncertain situations.

BASIC QUALIFICATIONS Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact. Bachelor’s degree 12+ years of commercial experience in the pharmaceutical industry Demonstrated experience and expertise leading and executing a successful global pharmaceutical/biotech oncology companion diagnostic launch Ability to work independently across senior level stakeholders and demonstrates judgement of what needs to be escalated Strong team player with demonstrated ability to engage experts from a wide range of functional areas to improve business performance and find a path forward Strong strategic thinking, analytical skills, detail and action oriented, creative, flexible, self-motivated Proven track record of translating key insights into meaningful strategies and tactics Excellent verbal and written communication skills for a wide range of audiences Solid understanding of today’s Global and US pharmaceutical environment, including Regulatory, Legal and Compliance Is a role model for the Pfizer Values

PREFERRED QUALIFICATIONS Advanced degree Oncology precision medicine experience required Companion diagnostic launch experience required

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS Ability to travel approximately 20% of the time

ROLE SUMMARY Breast cancer is the most common cancer affecting women in the US, and IBRANCE, our first-in-class CDK 4/6 inhibitor, along with TUKYSA, our best-in-class HER2 TKI, have been prescribed to over 200,000 patients since launch. In 2025, these two medicines contributed >$3.5B in net revenue to Pfizer Oncology and continue to be market leaders in their respective settings despite intensifying competition. In addition, Pfizer Oncology is preparing to launch novel medicines in breast cancer in the next few years, along with several indication expansions.

The HCP Marketing Director of NPP / Digital position is an opportunity for a results-driven marketing colleague who likes to solve complex business challenges in a dynamic, competitive marketplace. This individual will lead a number of critical and high-visibility commercial initiatives to defend and grow the TUKYSA business through the NPP/digital channels.

Given the complexity and interconnected nature of NPP/Digital execution, this position requires involvement and collaboration with the broader US Commercial team, Legal, Medical, Regulatory, Sales, Global, Operations and various other internal stakeholders.

As the HCP NPP/Digital channel Marketing Director, this individual will be responsible for leading the TUKYSA brand strategy in a digital/omnichannel capacity as well as optimizing the brand’s NPP execution and 1:1 targeting across the MBC and mCRC indications.

This role requires strong analytical and proactive thinking, clear and concise communication skills, lateral leadership ability, proficient project management and budget management skills, creativity, and a proven track record of success working on a large matrix team. As the HCP NPP / Digital Channel Marketing Director, this individual must be comfortable and working in ambiguity given that digital platforms, activations and requirements are constantly changing.

Additional opportunities and responsibilities will arise and be assigned based on interest, IDPs, and capabilities.

The TUKYSA US Marketing Team is dynamic with lots of opportunity; roles and responsibilities may shift due to business needs and the interests of the individual over time.

This role, Director, HCP NPP/Digital, will report to the US TUKYSA Marketing Brand Lead.

ROLE RESPONSIBILITIES Key Responsibilities include, but are not limited to: Lead translation of TUKYSA HCP MBC and mCRC brand strategies to NPP/Digital strategies and executions

Drive optimizations within the brand’s HCP MBC and mCRC NPP/Digital ecosystem and ways of working (i.e. develop insight-generating tests and pilots through the NPP/Digital channels; lean into performance/historical data to inform decision making; pioneer tactical, vendor and/or process efficiencies, etc.)

Lead and develop the HCP Branded and Unbranded Websites

across all indications ; this includes SEO/metadata and SEM/paid search strategy & implementation

Own decision making, vendor management, and scope of the $8-10M HCP TUKYSA Media budget (e.g., design, execution and channel-level spend)

Responsible for the HCP Home Office Email (CRM) channel

Develop video content for HCP audiences to live on our websites or third-party sites

Develop and maintain the HCP MBC Triggered Email & 3P Media journeys

Partner with our Digital Analytics colleagues/vendors to understand performance trends to adjust spend, vendor preference, creative, and flighting of tactics

Collaborate with other Pfizer Digital Marketing Leads or functions to cross-pollinate learnings

Mentor the Senior Product Manager, NPP / Congress

Manage multiple outside agencies and establish optimal ways of working between you and the vendor as well as vendor-to-vendor (i.e. facilitate status calls; manage cross-agency projects, timelines and hand-offs; execute projects from kick-off to MLR to launch while ensuring consistency with product positioning, brand guidelines, company goals, and ethics)

Lead annual Tactical Planning for the HCP NPP/Digital channel (across indications) to include website, media, and email planning

Participate in strategic brand discussions using market research, competitive intelligence/activity, advisory boards and clinical data as rationale for strategy

Identify and mitigate critical issues that impact your individual

or

cross-channel workstreams and project timelines

Proactively communicate digital strategy/activations to sales colleagues for awareness

BASIC QUALIFICATIONS Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability...