Director Clinical Development

Director Clinical Development - Biotech - homebased

Upsilon Global is partnering with an innovative and growing biotech organisation seeking a senior clinical leader to shape and drive their global development strategy. This is a high-impact role for a strategic decision-maker who wants ownership, visibility, and influence at executive level.

The Opportunity As Director Clinical Development, you will play a pivotal role in defining and executing the clinical strategy across early- to late-phase programs. You will work closely with executive leadership to align clinical, regulatory, and commercial objectives, ensuring assets are progressed efficiently toward key value inflection points and regulatory milestones. This position requires someone comfortable making critical portfolio decisions, guiding cross-functional teams, and representing the company externally with confidence and authority.

Key Responsibilities Lead and shape future clinical development strategy and clinical development plans, working closely with Development and Discovery Program Leads and counterparts in Regulatory, Clinical Development, Clinical Operations, Biostatistics, Clinical Pharmacology, Non-clinical and Discovery Research for assigned studies Assure clinical development plans are comprehensive, include key decision points, timely readouts, and risk mitigation for both near and long-term goals Plan and overall product strategy that meet ethical, scientific, safety, regulatory objectives Establish and maintain strong relationships with key opinion leaders and partners, to facilitate and support external collaborations Support site selection and site activation activities, including contacting investigators to discuss potential interest in assigned study, developing slides for site initiation visits (SIV), and performing SIVs as needed Provide medical oversight of assigned clinical studies including implementation, medical/safety monitoring, protocol compliance and medical data review Analyse and interpret data, identifying trends and signals, and synthesizing key learnings to impact subsequent phases of clinical development as well as to shape the translational medicine plans so they are complementary to the clinical development plans

Experience & Knowledge The ideal candidate is an MD or MD/PhD physician scientist with a clinical perspective, coupled with a track record of exceptional achievement in vaccines/infectious diseases therapy development. Strategic and critical thinker, with proven success in designing innovative clinical trials that have supported successful regulatory filings Track record of leading clinical teams and building mutually respectful relationships with colleagues; has the capability to listen to and integrate input from cross-functional teams and then make clear decisions Able to trouble shoot challenges and provide direction, guidance, and support to the team to deliver on near term goals

Education & Qualifications MD or MD/PhD with research training Working knowledge of basic and clinical science Strong understanding of pharmacokinetics, biomarkers, statistical principles, and regulatory requirements and demonstrated experience integrating these disciplines in the context of drug development. Broad understanding of infectious diseases area; experience in vaccines/infectious diseases highly desirable At least 3 years of relevant experience in clinical drug development across academia or pharmaceutical industry (must include experience conducting early phase trials) At least 2 years of experience as a medical monitor in a biotechnology/ pharmaceutical company, and/or CRO.

For more information, please apply or contact Upsilon Global directly on +44 203 875 9966.