ERC-Funded Postdoctoral Position in Epigenome Maintenance During DNA Replication at Gustave Rou[...]

Organisation/Company CNRS Gustave Roussy Department UMR9019 Genome integrity and cancers Research Field Biological sciences » Biology Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Application Deadline 1 May 2026 - 12:00 (Europe/Paris) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 May 2026 Is the job funded through the EU Research Framework Programme? Horizon 2020 Reference Number 101231320 Is the Job related to staff position within a Research Infrastructure? No Offer Description

We are offering afully funded 3-year postdoctoral positionto investigate the molecular mechanisms that ensure faithful epigenome maintenance during DNA replication. This position is supported by a European Research Council (ERC) grant and is availablefrom May 1st, 2026(flexible start date). Project Overview: Faithful transmission of cellular identity requires not only accurate DNA replication but also the preservation of chromatin organization and epigenetic information. During DNA replication, forks must coordinate DNA synthesis with chromatin reassembly, epigenetic mark inheritance, and maintenance of genome integrity across diverse chromatin states and physiological conditions. This project aims to uncovernovel mechanisms linking DNA replication, fork stability, and chromatin maintenance, with a particular focus on how replication asymmetry between leading and lagging strands constrains genome and epigenome maintenance. These strands differ in mutation rates, DNA damage repair, epigenetic mark inheritance, and transposable element silencing. The lagging strand, in particular, may represent a key source of (epi)genetic instability under pathological conditions such as cancer, yet the underlying mechanisms remain poorly understood. Understanding how disruptions in these processes contribute to cancer development and cell fate decisions is a central objective of the project. Experimental Systems and Approaches: Culturedhuman cell lines and mouse embryonic stem cells. The project involves thedevelopment and application of innovative genomic approaches to characterize new mechanisms of epigenome stability, combining experimental and computational analyses. Research Environment The laboratory is part of theUnit of Genome Integrity and Cancers (UMR9019)at theGustave Roussy Institute, Europe’s leading cancer center. Gustave Roussy combines cutting-edge basic research, clinical investigation, and technological innovation, and is located inVillejuif, in the southern area of Grand Paris. We offer

an international, highly collaborative research environment with access to state-of-the-art core facilities, including advanced imaging, genomics, and bioinformatics platforms. Candidates will receive mentorship, career development support, and administrative assistance, especially for international researchers. We actively support applications for national and international postdoctoral fellowships. The lab is involved in several national and international grants and institutional research programs. Salary and Funding: 3-year fully funded position (ERC) . Salary iscommensurate with experienceand follows national academic standards for postdoctoral researchers. To apply,

please submit a CV; a cover letter briefly describing your motivation and research interests, and contact information for2–3 referees. Applications and inquiries should be addressed to: nataliya.petryk@gustaveroussy.fr Where to apply

E-mail nataliya.petryk@gustaveroussy.fr Requirements

Research Field Biological sciences » Biology Education Level PhD or equivalent Skills/Qualifications Candidate Profile We are seeking ahighly motivated postdoctoral researcherwith: APh.D. or equivalentin genomics, epigenetics, bioinformatics, biostatistics, computational biology, or a related field Strong background inchromatin biology, epigenetic regulation, and/or genome stability Solid expertise inmolecular biology, single-cell and functional genomics Experience withnext-generation sequencing technologies Ability and willingness to participate inhands-on data analysis, including bioinformatics pipelines Specific Requirements A proven track record inepigenetic regulation, genome stability, or functional genomicsis required. Experience in collaborative and interdisciplinary research environments is highly valued.

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