Job offer

Organisation/Company INSERM U1112 Research Field Medical sciences Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Application Deadline 1 Apr 2026 - 23:59 (Europe/Paris) Country France Type of Contract Temporary Job Status Full-time Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? Yes Offer Description

As part of the CILIAS Project, the Postdoctoral Researcher will be responsible for investigating the mechanisms underlying retinal degeneration in the context of ciliopathies, with a particular focus on Alström syndrome, using both in vivo models (particularly murine models) and in vitro systems (fibroblasts, iPSCs, retinal organoids, and RPE). Responsibilities: Establishment and colony management, including operational aspects related to the production and analysis of the ALMS mouse lines selected by the consortium. Close collaboration with the Research Engineer (AI) of UMRS_1112 at CRBS, who will be partially assigned to the project. Organization and implementation of experimental work involving mouse models: functional analyses (including ERG and OCT), development of additional functional assays, locally conducted histological analyses, and preparation of samples for collaboration with the Lyon-based team, including quality control of transferred materials and follow-up of results for interpretation. Analysis of fibroblasts, iPSCs, retinal organoids, and RPE models already generated by the laboratory, as well as the development of new models depending on the variants under investigation. Acting as a regular point of contact within the collaboration with the Lyon-based team. Contribution to data analysis and preparation of manuscripts within the framework of the ANR project and related projects on retinal ciliopathies. Required Skills and Qualifications: Certification/authorization for animal experimentation (mouse models), with demonstrated autonomy in colony supervision (breeding and experimental management), data analysis, and synthesis of results, with a strong focus on retinal analysis; ability to collaborate effectively with the Research Engineer. Solid expertise in cellular and molecular biology, including advanced cell culture techniques (notably iPSCs and organoids). Foundational expertise in retinal histology, including experience relevant to ciliopathies and familiarity with approaches developed by the Lyon team (U-ExM).

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