Job offer

TREX Laboratory (Translational Research and Experimental Corneal Surgery)

Organisation/Company Fondation Hôpital Rothschild Department TREX Laboratory (Translational Research and Experimental Corneal Surgery) Research Field Biological sciences » Biological engineering Researcher Profile Recognised Researcher (R2) Established Researcher (R3) Positions Postdoc Positions Application Deadline 25 Mar 2026 - 12:00 (Europe/Paris) Country France Type of Contract Temporary Job Status Full-time Offer Starting Date 15 Apr 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Structure & Research environment

The candidate will join the TREX laboratory (Translational Research and Experimental Corneal Surgery) at the Hôpital Fondation Rothschild (HFAR), directed by Prof. Eric Gabison (HFAR / University Paris Cité / INSERM U1342, Institut de Recherche Saint-Louis (IRSL), «Stem Cells Biotechnologies» team). The team is composed of researchers, physicians, pharmacists, and engineers, and focuses on corneal diseases, from understanding physiopathological mechanisms to developing targeted therapeutic strategies.

Scientific context & Research project

Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) are gaining considerable attention due to their strong translational potential. They are emerging as promising alternatives to conventional cell therapies, particularly because of their delivery capabilities and immunomodulatory and regenerative properties. The present project aims to develop an innovative EV-based therapeutic strategy using genetically engineered MSCs to provide novel treatment options for two rare ocular surface diseases leading progressively to blindness. The project is funded by AFM-Téléthon and conducted within a consortium of laboratories based in Paris.

Mission

The successful candidate will design, conduct, and coordinate complex experimental work, including optimization of gene expression tools in primary human cells, advanced cell culture and characterization, as well as purification and molecular characterization of bioengineered EVs. The project involves functional and therapeutic assessment in vitro and in vivo using dedicated cellular and animal models. Long-term objectives include adaptation to GMP-compatible procedures to enable clinical translation.

- Three-year fixed term contract - Salary according to experience ; access to HFAR cafeteria and employee benefits - Starting date : Spring 2026

>>> Applications, including a CV, cover letter, and contact details of referees should be sent to : Dr. Benoit Souquet (PhD), Researcher and Lab Manager – bsouquet@for.paris and Dr. Iris Marangon (PhD), Researcher - imarangon@for.paris

Where to apply E-mail imarangon@for.paris

Requirements Research Field Biological sciences » Biological engineering Education Level PhD or equivalent

Skills/Qualifications

Profile :

- PhD in cell biology or a related field, with 1–3 years of postdoctoral experience preferred - Experience in gene expression systems, primary cell culture, and strong expertise in EV research - Certification in animal experimentation and surgical procedures are a plus - Ability to work in a collaborative, multi-site research environment

Years of Research Experience 1 - 4

Additional Information Work Location(s) Number of offers available 1 Company/Institute Fondation Hôpital Rothschild, TREX Laboratory Country France City Paris Postal Code 75019 Street 25 Rue Manin Geofield

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