Director, Enterprise Applications

Position Summary Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI‑integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader‑based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease. This role owns the business systems that support Nurix's path from clinical trials through commercialization. You will be the primary IT partner to Clinical Operations, Regulatory, Quality, and Commercial leadership, ensuring the technology they depend on works and evolves with the business.

Primary Responsibilities

Serve as primary IT partner to Clinical Operations, Regulatory, Quality, and Commercial

Translate business needs into system requirements and implementation plans

Own stakeholder satisfaction for the enterprise applications portfolio

Proactively identify technology opportunities that enable business outcomes

Application Portfolio Management

Own the clinical, quality, regulatory, and commercial application portfolio

Current systems: Medidata Rave (EDC), Wingspan eTMF, Argus (pharmacovigilance), Veeva Vault RIM (submissions), Veeva CRM, Veeva QMS, VeevaDocs, Veeva Training

ERP/back‑office systems as commercial operations expand

Define application roadmap aligned to clinical milestones and commercial readiness

Manage system integrations, data flows, and reporting needs

Implementation and Delivery

Lead implementations end‑to‑end: requirements, configuration, testing, training, go‑live

Coordinate with clinical PM contractor on project execution

Align with IT Project Manager on resource conflicts, shared vendors, and portfolio reporting

Manage UAT coordination, training development, and change management

Vendor Management

Own functional relationships with application vendors (what gets built, does it work, is it adopted)

Partner with Director, IT Strategy & Vendor Operations on contracts, SOWs, and vendor governance

Hold vendors accountable for delivery outcomes and service quality

Ensure vendors build internal capability, not dependency

Compliance and Quality

Partner with Quality on GxP validation requirements for regulated systems

Understand CSV principles; work alongside Qualitas and internal validation resources

Support FDA inspection readiness for IT‑related controls

Ensure 21 CFR Part 11 compliance for electronic records and signatures organization

Required Qualifications

10+ years in IT, with 5+ years in life sciences or pharmaceutical environments

Direct experience with clinical systems: EDC, eTMF, CTMS, safety/PV, or regulatory submissions

Veeva platform experience (Vault, CRM, QMS)

Medidata Rave experience

Track record leading application implementations from requirements through adoption

Experience managing vendors for delivery outcomes (not just contract administration)

Working knowledge of GxP validation principles and 21 CFR Part 11

Strong business analyst skills: requirements gathering, process design, stakeholder facilitation

Comfortable with hands‑on configuration and troubleshooting when needed

Effective communicator with scientific, clinical, and business audiences

Bachelor's degree in a technical field, or equivalent experience

Strongly Preferred Qualifications

Experience supporting regulatory submissions or FDA inspection readiness

Commercial systems experience (CRM, market access, patient services)

ERP implementation or administration experience

Organization Reports to: SVP IT

Key Partners

Director, IT Operations (contracts, vendor governance, shared infrastructure)

IT Project Manager (portfolio coordination, resource alignment)

Clinical PM contractor (implementation project execution)

Sr. Director and CISO (security, compliance)

USDM (system validation, GxP compliance)

Primary Stakeholders

Clinical Operations leadership

Regulatory Affairs leadership

Quality leadership

Commercial leadership

Salary Range $216,000 to $251,000 Plus Bonus and Equity

Location Brisbane, CA - Onsite

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